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  1. Sun Z, Heacock-Kang Y, McMillan IA, Cabanas D, Zarzycki-Siek J, Hoang TT. A virulence activator of a surface attachment protein in Burkholderia pseudomallei acts as a global regulator of other membrane-associated virulence factors. Frontiers in Microbiology. 2022;13:1063287. doi: 10.3389/fmicb.2022.1063287. eCollection 2022. PubMed PMID: 36726566; PubMed Central PMCID: PMC9884982.

  2. McMillan IA, Norris MH, Zarzycki-Siek J, Heacock-Kang Y, Sun Z, Borlee BR, Hoang TT. Identification of a PadR-type regulator essential for intracellular pathogenesis of Burkholderia pseudomallei. Scientific Reports. 2021 May 17;11(1):10405. doi: 10.1038/s41598-021-89852-7. PubMed PMID: 34001967; PubMed Central PMCID: PMC8128862.

  3. Heacock-Kang Y, McMillan IA, Norris MH, Sun Z, Zarzycki-Siek J, Bluhm AP, Cabanas D, Norton RE, Ketheesan N, Miller JF, Schweizer HP, Hoang TT. The Burkholderia pseudomallei intracellular 'TRANSITome'Nature Communications. 2021 Mar 26;12(1):1907. doi: 10.1038/s41467-021-22169-1. PubMed PMID: 33772012; PubMed Central PMCID: PMC7998038.

  4. Heacock-Kang Y, Sun Z, Zarzycki-Siek J, Poonsuk K, McMillan IA, Chuanchuen R, Hoang TT. Two Regulators, PA3898 and PA2100, Modulate the Pseudomonas aeruginosa Multidrug Resistance MexAB-OprM and EmrAB Efflux Pumps and Biofilm FormationAntimicrobial Agents and Chemotherapy. 2018 Dec;62(12). doi: 10.1128/AAC.01459-18. Print 2018 Dec. PubMed PMID: 30297364; PubMed Central PMCID: PMC6256797.

  5. Heacock-Kang Y, McMillan IA, Zarzycki-Siek J, Sun Z, Bluhm AP, Cabanas D, Hoang TT. The heritable natural competency trait of Burkholderia pseudomallei in other Burkholderia species through comE and crpScientific Reports. 2018 Aug 20;8(1):12422. doi: 10.1038/s41598-018-30853-4. PubMed PMID: 30127446; PubMed Central PMCID: PMC6102250.

  6. Heacock-Kang Y, Zarzycki-Siek J, Sun Z, Poonsuk K, Bluhm AP, Cabanas D, Fogen D, McMillan IA, Chuanchuen R, Hoang TT. Novel dual regulators of Pseudomonas aeruginosa essential for productive biofilms and virulenceMolecular Microbiology. 2018 Aug;109(3):401-414. doi: 10.1111/mmi.14063. Epub 2018 Jul 31. PubMed PMID: 29995308; PubMed Central PMCID: PMC6158065.

  7. Norris MH, Heacock-Kang Y, Zarzycki-Siek J, Bluhm AP, McMillan IA, Schweizer HP, Hoang TT. Burkholderia pseudomallei natural competency and DNA catabolism: Identification and characterization of relevant genes from a constructed fosmid libraryPLoS One. 2017;12(12):e0189018. doi: 10.1371/journal.pone.0189018. eCollection 2017. PubMed PMID: 29253888; PubMed Central PMCID: PMC5734746.

  8. Heacock-Kang Y, Sun Z, Zarzycki-Siek J, McMillan IA, Norris MH, Bluhm AP, Cabanas D, Fogen D, Vo H, Donachie SP, Borlee BR, Sibley CD, Lewenza S, Schurr MJ, Schweizer HP, Hoang TT. Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architectureMolecular Microbiology. 2017 Dec;106(6):976-985. doi: 10.1111/mmi.13863. Epub 2017 Nov 17. PubMed PMID: 29030956; PubMed Central PMCID: PMC5720903.

  9. Kang Y, McMillan I, Norris MH, Hoang TT. Single prokaryotic cell isolation and total transcript amplification protocol for transcriptomic analysis. Nature Protocols. 2015 Jul;10(7):974-84. doi: 10.1038/nprot.2015.058. Epub 2015 Jun 4. PubMed PMID: 26042386; PubMed Central PMCID: PMC4494743.

  10. Belcaid M, Kang Y, Tuanyok A, Hoang TT. Complete Genome Sequence of Burkholderia cepacia Strain LO6. Genome Announcements. 2015 Jun 11;3(3). doi: 10.1128/genomeA.00587-15. PubMed PMID: 26067955; PubMed Central PMCID: PMC4481279.

  11. Sun Z, Kang Y, Norris MH, Troyer RM, Son MS, Schweizer HP, Dow SW, Hoang TT. Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivoPLoS One. 2014;9(7):e103778. doi: 10.1371/journal.pone.0103778. eCollection 2014. PubMed PMID: 25068317; PubMed Central PMCID: PMC4113454.

  12. Zarzycki-Siek J, Norris MH, Kang Y, Sun Z, Bluhm AP, McMillan IA, Hoang TT. Elucidating the Pseudomonas aeruginosa fatty acid degradation pathway: identification of additional fatty acyl-CoA synthetase homologuesPLoS One. 2013;8(5):e64554. doi: 10.1371/journal.pone.0064554. Print 2013. PubMed PMID: 23737986; PubMed Central PMCID: PMC3667196.

  13. Norris MH, Propst KL, Kang Y, Dow SW, Schweizer HP, Hoang TT. The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in miceInfection and Immunity. 2011 Oct;79(10):4010-8. doi: 10.1128/IAI.05044-11. Epub 2011 Aug 1. PubMed PMID: 21807903; PubMed Central PMCID: PMC3187240.

  14. Kang Y, Norris MH, Wilcox BA, Tuanyok A, Keim PS, Hoang TT. Knockout and pullout recombineering for naturally transformable Burkholderia thailandensis and Burkholderia pseudomalleiNature Protocols. 2011 Jul 7;6(8):1085-104. doi: 10.1038/nprot.2011.346. PubMed PMID: 21738123; PubMed Central PMCID: PMC3564556.

  15. Kang Y, Norris MH, Zarzycki-Siek J, Nierman WC, Donachie SP, Hoang TT. Transcript amplification from single bacterium for transcriptome analysis. Genome Research. 2011 Jun;21(6):925-35. doi: 10.1101/gr.116103.110. Epub 2011 May 2. PubMed PMID: 21536723; PubMed Central PMCID: PMC3106325.

  16. Norris MH, Kang Y, Wilcox B, Hoang TT. Stable, site-specific fluorescent tagging constructs optimized for Burkholderia speciesApplied and Environmental Microbiology. 2010 Nov;76(22):7635-40. doi: 10.1128/AEM.01188-10. Epub 2010 Sep 17. PubMed PMID: 20851961; PubMed Central PMCID: PMC2976199.

  17. Kang Y, Zarzycki-Siek J, Walton CB, Norris MH, Hoang TT. Multiple FadD acyl-CoA synthetases contribute to differential fatty acid degradation and virulence in Pseudomonas aeruginosaPLoS One. 2010 Oct 21;5(10):e13557. doi: 10.1371/journal.pone.0013557. PubMed PMID: 21042406; PubMed Central PMCID: PMC2958839.

  18. Norris MH, Kang Y, Lu D, Wilcox BA, Hoang TT. Glyphosate resistance as a novel select-agent-compliant, non-antibiotic-selectable marker in chromosomal mutagenesis of the essential genes asd and dapB of Burkholderia pseudomalleiApplied and Environmental Microbiology. 2009 Oct;75(19):6062-75. doi: 10.1128/AEM.00820-09. Epub 2009 Jul 31. PubMed PMID: 19648360; PubMed Central PMCID: PMC2753064.

  19. Kang Y, Lunin VV, Skarina T, Savchenko A, Schurr MJ, Hoang TT. The long-chain fatty acid sensor, PsrA, modulates the expression of rpoS and the type III secretion exsCEBA operon in Pseudomonas aeruginosaMolecular Microbiology. 2009 Jul;73(1):120-36. doi: 10.1111/j.1365-2958.2009.06757.x. Epub 2009 Jun 8. PubMed PMID: 19508282; PubMed Central PMCID: PMC2759274.

  20. Kang Y, Norris MH, Barrett AR, Wilcox BA, Hoang TT. Engineering of tellurite-resistant genetic tools for single-copy chromosomal analysis of Burkholderia spp. and characterization of the Burkholderia thailandensis betBA operonApplied and Environmental Microbiology. 2009 Jun;75(12):4015-27. doi: 10.1128/AEM.02733-08. Epub 2009 Apr 17. PubMed PMID: 19376905; PubMed Central PMCID: PMC2698364.

  21. Barrett AR, Kang Y, Inamasu KS, Son MS, Vukovich JM, Hoang TT. Genetic tools for allelic replacement in Burkholderia speciesApplied and Environmental Microbiology. 2008 Jul;74(14):4498-508. doi: 10.1128/AEM.00531-08. Epub 2008 May 23. PubMed PMID: 18502918; PubMed Central PMCID: PMC2493169.

  22. Kang Y, Nguyen DT, Son MS, Hoang TT. The Pseudomonas aeruginosa PsrA responds to long-chain fatty acid signals to regulate the fadBA5 beta-oxidation operonMicrobiology. 2008 Jun;154(Pt 6):1584-1598. doi: 10.1099/mic.0.2008/018135-0. PubMed PMID: 18524913.

  23. Son MS, Nguyen DT, Kang Y, Hoang TT. Engineering of FRT-lacZ fusion constructs: induction of the Pseudomonas aeruginosa fadAB1 operon by medium and long chain-length fatty acidsPlasmid. 2008 Mar;59(2):111-8. doi: 10.1016/j.plasmid.2007.12.002. Epub 2008 Jan 25. PubMed PMID: 18221997; PubMed Central PMCID: PMC2276238.

  24. Son MS, Matthews WJ Jr, Kang Y, Nguyen DT, Hoang TT. In vivo evidence of Pseudomonas aeruginosa nutrient acquisition and pathogenesis in the lungs of cystic fibrosis patients. Infection and Immunity. 2007 Nov;75(11):5313-24. doi: 10.1128/IAI.01807-06. Epub 2007 Aug 27. PubMed PMID: 17724070; PubMed Central PMCID: PMC2168270.

  25. Kang Y, Son MS, Hoang TT. One step engineering of T7-expression strains for protein production: increasing the host-range of the T7-expression systemProtein Expression and Purification. 2007 Oct;55(2):325-33. doi: 10.1016/j.pep.2007.06.014. Epub 2007 Jul 12. PubMed PMID: 17716915; PubMed Central PMCID: PMC2040312.

  26. Yamniuk AP, Nguyen LT, Hoang TT, Vogel HJ. Metal ion binding properties and conformational states of calcium- and integrin-binding proteinBiochemistry. 2004 Mar 9;43(9):2558-68. doi: 10.1021/bi035432b. PubMed PMID: 14992593.

  27. Hoang TT, Sullivan SA, Cusick JK, Schweizer HP. Beta-ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengthsMicrobiology . 2002 Dec;148(Pt 12):3849-3856. doi: 10.1099/00221287-148-12-3849. PubMed PMID: 12480888.

  28. Chuanchuen R, Beinlich K, Hoang TT, Becher A, Karkhoff-Schweizer RR, Schweizer HP. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJAntimicrobial Agents and Chemotherapy. 2001 Feb;45(2):428-32. doi: 10.1128/AAC.45.2.428-432.2001. PubMed PMID: 11158736; PubMed Central PMCID: PMC90308.

  29. Schweizer HP, Hoang TT, Propst KL, Ornelas HR, Karkhoff-Schweizer RR. Vector design and development of host systems for PseudomonasGenetic Engineering. 2001;23:69-81. doi: 10.1007/0-306-47572-3_5. Review. PubMed PMID: 11570107.

  30. Barekzi N, Beinlich K, Hoang TT, Pham XQ, Karkhoff-Schweizer R, Schweizer HP. High-frequency flp recombinase-mediated inversions of the oriC-containing region of the Pseudomonas aeruginosa genomeJournal of Bacteriology. 2000 Dec;182(24):7070-4. doi: 10.1128/jb.182.24.7070-7074.2000. PubMed PMID: 11092871; PubMed Central PMCID: PMC94836.

  31. Hoang TT, Kutchma AJ, Becher A, Schweizer HP. Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strainsPlasmid. 2000 Jan;43(1):59-72. doi: 10.1006/plas.1999.1441. PubMed PMID: 10610820.

  32. Hoang TT, Ma Y, Stern RJ, McNeil MR, Schweizer HP. Construction and use of low-copy number T7 expression vectors for purification of problem proteins: purification of mycobacterium tuberculosis RmlD and pseudomonas aeruginosa LasI and RhlI proteins, and functional analysis of purified RhlIGene. 1999 Sep 17;237(2):361-71. doi: 10.1016/s0378-1119(99)00331-5. PubMed PMID: 10521660.

  33. Hoang TT, Schweizer HP. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesisJournal of Bacteriology. 1999 Sep;181(17):5489-97. doi: 10.1128/JB.181.17.5489-5497.1999. PubMed PMID: 10464225; PubMed Central PMCID: PMC94060.

  34. Kutchma AJ, Hoang TT, Schweizer HP. Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD)Journal of Bacteriology. 1999 Sep;181(17):5498-504. doi: 10.1128/JB.181.17.5498-5504.1999. PubMed PMID: 10464226; PubMed Central PMCID: PMC94061.

  35. Hoang TT, Karkhoff-Schweizer RR, Kutchma AJ, Schweizer HP. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutantsGene. 1998 May 28;212(1):77-86. doi: 10.1016/s0378-1119(98)00130-9. PubMed PMID: 9661666.

  36. Handfield M, Schweizer HP, Mahan MJ, Sanschagrin F, Hoang T, Levesque RC. ASD-GFP vectors for in vivo expression technology in Pseudomonas aeruginosa and other gram-negative bacteriaBiotechniques. 1998 Feb;24(2):261-4. doi: 10.2144/98242st02. PubMed PMID: 9494727.

  37. Hoang TT, Schweizer HP. Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and characterization of the fabAB operon encoding beta-hydroxyacyl-acyl carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier protein synthase I (FabB)Journal of Bacteriology. 1997 Sep;179(17):5326-32. doi: 10.1128/jb.179.17.5326-5332.1997. PubMed PMID: 9286984; PubMed Central PMCID: PMC179400.

  38. Hoang TT, Schweizer HP. Identification and genetic characterization of the Pseudomonas aeruginosa leuB gene encoding 3-isopropylmalate dehydrogenaseMolecular Genetics and Genomics. 1997 Mar 26;254(2):166-70. doi: 10.1007/s004380050404. PubMed PMID: 9108278.

  39. Hoang TT, Williams S, Schweizer HP, Lam JS. Molecular genetic analysis of the region containing the essential Pseudomonas aeruginosa asd gene encoding aspartate-beta-semialdehyde dehydrogenaseMicrobiology. 1997 Mar;143 ( Pt 3):899-907. doi: 10.1099/00221287-143-3-899. PubMed PMID: 9084174.

  40. Schweizer HP, Hoang TT. An improved system for gene replacement and xylE fusion analysis in Pseudomonas aeruginosaGene. 1995 May 26;158(1):15-22. doi: 10.1016/0378-1119(95)00055-b. PubMed PMID: 7789804.

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